THE JOURNAL OF ANTIBIOTICS SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonosporasp. II. Structure Determination
نویسندگان
چکیده
SB-219383 (1), isolated from fermentation broth of a novel species ofMicromonospora sp. NCIMB40684, is the first member of a new class of compounds having inhibitory activity against tyrosyl tRNA synthetase (IC50, 2nM). SB-219383 also exhibits moderate in vitro activity against some Gram-positive bacteria. The preceding paper describes the fermentation, isolation, physico-chemical and biological properties of 11}. The structure elucidation of SB-219383 is reported in this paper. The structure of 1 as well as its 9-fluorenylmethoxycarbonyl (FMOC) methyl ester (2) are shown in Fig. 1.
منابع مشابه
Confirmation of the antibacterial mode of action of SB-219383, a novel tyrosyl tRNA synthetase inhibitor from a Micromonospora sp.
The compound designated SB-219383 is a potent and selective inhibitor of bacterial tyrosyl tRNA synthetases. It exhibits an IC50 of < 1 nM against Staphylococcus aureus tyrosyl tRNA synthetase and weak in vitro activity against Staphylococci and Streptococci. Here we present data consistent with SB-219383 eliciting an amino acid starvation in both S. aureus and Streptococcus pneumoniae, support...
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